| Dulé Hill as | Charlie (Charles) Young | Personal Aide to the President | |
| Allison Janney as | C.J. (Claudia Jean) Cregg | Press Secretary | |
| Janel Moloney as | Donna (Donnatella) Moss | Assistant to Deputy Chief of Staff | |
| Richard Schiff as | Toby (Tobias Zachary) Ziegler | Communications Director | |
| John Spencer as | Leo Thomas McGarry | Chief of Staff | |
| Bradley Whitford as | Josh (Joshua) Lyman | Deputy Chief of Staff | |
| and Martin Sheen as |
Jed (Josiah Edward) Bartlet | President of the United States | |
| Clark Gregg as | Special Agent Michael Casper | "Mike" / FBI | |
| Sam Robards as | Greg Brock | Reporter | |
| Albie Selznick as | Todd Schumaker | Documentarian | |
| NiCole Robinson as | Margaret | Hooper (last name) / Assistant to Chief of Staff |
|
| Wilson Cruz as | Jack Sosa | Asst. Press Secretary for Domestic Policy | |
| Michael Gallagher as | Andrew Weltzman | Asst. Press Secretary for Foreign Policy | |
| Michael Kagan as | George Arnold | FBI Director | |
| Joseph Vassallo as | Renato Mannari | Vatican Advance | |
| Narration by | Will Lyman | ||
| Co-Starring | |||
| Melissa Fitzgerald as | Carol | Fitzpatrick (last name) Assistant to the Press Secretary |
|
| Mindy Seeger as | Chris | Reporter | |
| Kris Murphy as | Katie | Witt (last name) / Reporter | |
| Joyce Guy as | Charlayne | Reporter | |
| Charles Noland as | Steve | Reporter | |
| Timothy Davis-Reed as | Mark | O'Donnell (last name) / Reporter | |
| Harper Roisman as | Herb Morris | Retired Washington Evening Star Reporter | |
| Brian Poth as | Eric | Schaeffer (last name) / Staff Assistant | |
| Paul Jenkins as | Martin Sheffield | Former Press Secretary | |
| James Ingersoll as | Cable News Pundit | ||
| Ivan Allen as | Anchor | Roger Salier | |
| Lee Oliver Boyd as | Cable Anchor | ||
| Alan Toy as | Franklin | Reporter | |
| David Castellani as | Reporter On-Site | ||
| Kellynn Jones as | 2nd On-Site Reporter | ||
| Rebecca Avery as | Anna | Reporter | |
| Hira Ambrosino as | White House Correspondent | ||
| Kenneth Schmidt as | Craig Bloom | ||
| Kevin Symons as | FBI Press Rep | ||
| Sharon Johnston as | Terrance Neighbor |
... And it is a very difficult job because you are the servant of two masters. And Joe Lockhart, once, actually let me start a press briefing in Washington, and it was strange. I felt strangely comfortable, though, going in there. But [UPI White House correspondent] Helen Thomas came up to me afterwards, and she said, "I just want to give you some advice. As the press secretary, you represent the American people. That's who you represent. You can't--" I mean, she was basically telling me that I had to tell, give up the goods to the press and to the people because that was where my duty lay, where my obligation was and not to the president. And I was like, "Well, Helen, I'll take that under consideration." - Allison Janney
"Popular Politics"
by Terence Smith
September 27, 2000
Online NewsHour with Jim Lehrer
Janney has followed the work of real White House press secretaries over the years. She considers the departing Ari Fleischer "very slick and unflappable and brilliant. It's really tough, and I think Ari did an amazing job."But he's not her favorite press secretary. That was Mike McCurry of the Clinton administration.
"He had the best relationship with the press and was a master of serving two masters and walking that fine line between them."
"Janney leaps successfully from TV to big screen"
by Bruce Westbrook
July 29, 2003
Houston Chronicle